Reference for IQC
Maximum imprecision by analyte
See desirable imprecision specification based on 50% intraindividual coefficient of variation (CVI). Check the matrix and study conditions at the source before applying the value.
Data consulted on 9/15/2026. The table remains available even without connection to the external source.
191 references available
| Analyte | Matrix | CVI (%) | 0.5 × CVI (%) | Font Update |
|---|---|---|---|---|
| 17-alphahydroxyprogesterone | Serum/plasma | 23.66 | 11.83 | 3/27/2025 |
| 25-hydroxyvitamin D3 | Serum/plasma | 6.76 | 3.38 | 9/9/2026 |
| Adiponectin | Serum/plasma | 16.93 | 8.47 | 9/3/2025 |
| Alanine transaminase (ALT/TPG) | Serum/plasma | 12.64 | 6.32 | 3/27/2026 |
| Albumin | Serum/plasma | 2.5 | 1.25 | 5/6/2026 |
| Glycated albumin | Serum/plasma | 1.41 | 0.71 | 9/3/2025 |
| Aldosterone | Serum/plasma | 36.6 | 18.3 | 9/3/2025 |
| alpha-1 antitrypsin | Serum/plasma | 3.8 | 1.9 | 8/13/2025 |
| Alpha-1-acid glycoprotein | Serum/plasma | 7.36 | 3.68 | 8/13/2025 |
| Alpha-2-antiplasmin | Plasma | 5.75 | 2.88 | 2/19/2025 |
| Alphafetoprotein | Serum/plasma | 4.56 | 2.28 | 2/19/2025 |
| Alkaline phosphatase (ALP) — total | Serum/plasma | 5.25 | 2.62 | 9/9/2026 |
| Amylase | Serum/plasma | 6.77 | 3.38 | 9/9/2026 |
| Pancreatic amylase | Serum/plasma | 6.65 | 3.33 | 2/19/2025 |
| Androstenedione | Serum/plasma | 19.23 | 9.62 | 3/27/2026 |
| ADAMTS-13 Antigen | Plasma | 9.75 | 4.88 | 2/19/2025 |
| Carcinoembryonic antigen (CEA) | Serum/plasma | 6.83 | 3.42 | 6/27/2025 |
| Antithrombin Antigen | Plasma | 7.2 | 3.6 | 2/19/2025 |
| Protein C antigen | Plasma | 2.2 | 1.1 | 2/19/2025 |
| Protein S antigen (free) | Plasma | 4.16 | 2.08 | 2/19/2025 |
| Protein S antigen (total) | Plasma | 6.86 | 3.43 | 3/27/2025 |
| Tissue plasminogen activator antigen (t-PA ag) | Plasma | 13.3 | 6.65 | 2/19/2025 |
| Cancer Antigen 125 (CA-125) | Serum/plasma | 8.73 | 4.36 | 6/23/2025 |
| Cancer antigen 19-9 (CA 19-9) | Serum/plasma | 4.34 | 2.17 | 3/27/2025 |
| von Willebrand factor antigen | Plasma | 12.71 | 6.36 | 2/19/2025 |
| Plasminogen activator inhibitor 1 antigen (PAI-1 Ag) | Plasma | 48.63 | 24.31 | 2/19/2025 |
| Prostate-specific antigen (PSA) | Serum/plasma | 6.8 | 3.4 | 3/27/2026 |
| Prostate specific antigen (PSA) - conjugate | Serum/plasma | 8.8 | 4.4 | 2/19/2025 |
| Prostate specific antigen (PSA) - free | Serum/plasma | 7.1 | 3.55 | 2/19/2025 |
| Apolipoprotein A1 | Serum/plasma | 4.71 | 2.35 | 5/6/2026 |
| Apolipoprotein B | Serum/plasma | 6.2 | 3.1 | 5/6/2026 |
| Aspartate transaminase (AST/TGO) | Serum/plasma | 8.58 | 4.29 | 8/13/2025 |
| ADAMTS-13 Activity | Plasma | 12.73 | 6.37 | 2/19/2025 |
| Antithrombin activity | Plasma | 3.43 | 1.72 | 5/15/2025 |
| Gamma-glutamyl transferase activity | Serum/plasma | 8.29 | 4.15 | 8/13/2025 |
| Lactate dehydrogenase (LDH) activity | Serum/plasma | 4.36 | 2.18 | 3/27/2026 |
| Protein C Activity | Plasma | 5.68 | 2.84 | 3/27/2025 |
| Protein S Activity | Plasma | 7.33 | 3.66 | 2/19/2025 |
| Von Willebrand activity (collagen binding) | Plasma | 25.6 | 12.8 | 2/19/2025 |
| Tissue plasminogen activator activity (t-PA act) | Plasma | 32 | 16 | 2/19/2025 |
| Factor VII (F7) Activity | Plasma | 9.29 | 4.64 | 5/15/2025 |
| Factor VIII (F8) Activity | Plasma | 8.7 | 4.35 | 5/15/2025 |
| von Willebrand factor activity | Plasma | 16.97 | 8.48 | 2/19/2025 |
| Factor XII Activity (F12) | Plasma | 4 | 2 | 2/19/2025 |
| Plasminogen activator inhibitor 1 (PAI-1 Act) activity | Plasma | 34.94 | 17.47 | 2/19/2025 |
| Basophils | Whole blood | 12.6 | 6.3 | 1/21/2026 |
| Standard Bicarbonate | Serum/plasma | 4.2 | 2.1 | 2/19/2025 |
| Real bicarbonate | Whole blood | 4 | 2 | 3/5/2025 |
| Bilirubin | Serum/plasma | 20.18 | 10.09 | 8/13/2025 |
| Conjugated bilirubin (direct) | Serum/plasma | 19.55 | 9.78 | 10/20/2025 |
| C-terminal cross-linked telopeptide of type I collagen (CTX) | Serum/plasma | 14.49 | 7.24 | 5/15/2025 |
| Neurofilament Light Chain (NF-L) | Serum/plasma | 8.64 | 4.32 | 2/19/2025 |
| Free kappa light chain | Serum/plasma | 5.88 | 2.94 | 3/5/2025 |
| Free lambda light chain | Serum/plasma | 5.6 | 2.8 | 3/5/2025 |
| Calcitonin | Serum/plasma | 13 | 6.5 | 2/19/2025 |
| Cancer antigen 72-4 (CA 72-4) | Serum/plasma | 50.3 | 25.15 | 2/19/2025 |
| Ceruloplasmin | Serum/plasma | 4.98 | 2.49 | 3/25/2026 |
| Cystatin C | Serum/plasma | 3.3 | 1.65 | 2/20/2026 |
| Chloride | Serum/plasma | 0.97 | 0.49 | 3/27/2026 |
| Cobalamin | Serum/plasma | 7.25 | 3.62 | 2/19/2025 |
| Copper | Serum/plasma | 7.83 | 3.92 | 4/13/2026 |
| Cholesterol | Serum/plasma | 5.26 | 2.63 | 9/9/2026 |
| HDL Cholesterol | Serum/plasma | 5.74 | 2.87 | 5/6/2026 |
| LDL Cholesterol | Serum/plasma | 7.43 | 3.72 | 5/6/2026 |
| Complement 3 (C3) | Serum/plasma | 4.6 | 2.3 | 8/13/2025 |
| Complement 4 (C4) | Serum/plasma | 6.9 | 3.45 | 8/13/2025 |
| Alpha 2-antiplasmin/plasmin complex | Plasma | 18.2 | 9.1 | 2/19/2025 |
| t-PA/PAI-1 Complex | Plasma | 19.27 | 9.64 | 2/19/2025 |
| Thrombin-antithrombin complex | Plasma | 18.97 | 9.49 | 2/19/2025 |
| Mean corpuscular hemoglobin concentration (MCHC) | Whole blood | 0.97 | 0.49 | 2/11/2026 |
| Copeptin | Serum/plasma | 18.51 | 9.25 | 2/19/2025 |
| Cortisol | Serum/plasma | 16.15 | 8.08 | 3/27/2026 |
| Creatine kinase (CPK) | Serum/plasma | 14.12 | 7.06 | 3/27/2026 |
| Creatinine | Serum/plasma | 4.39 | 2.19 | 5/6/2026 |
| Chromogranin A | Serum/plasma | 14.82 | 7.41 | 2/19/2025 |
| Calcium (Ca) | Serum/plasma | 1.81 | 0.9 | 5/6/2026 |
| D-dimer | Plasma | 25.24 | 12.62 | 2/19/2025 |
| Red Blood Cell Distribution Standard Deviation (RDW-SD) | Whole blood | 1.65 | 0.83 | 2/11/2026 |
| Dihydrotestosterone (DHT) | Serum/plasma | 11.6 | 5.8 | 2/19/2025 |
| Carbon dioxide (total) | Whole blood | 4 | 2 | 3/5/2025 |
| Neuron-specific enolase | Serum/plasma | 10.89 | 5.45 | 2/19/2025 |
| Eosinophils | Whole blood | 15.08 | 7.54 | 1/21/2026 |
| Erythrocytes | Whole blood | 2.61 | 1.31 | 2/11/2026 |
| Estradiol | Serum/plasma | 15 | 7.5 | 3/27/2025 |
| Fibroblast Growth Factor 23 | Serum/plasma | 14.03 | 7.01 | 2/19/2025 |
| Insulin-like growth factor 1 (IGF-1) | Serum/plasma | 9.4 | 4.7 | 2/19/2025 |
| Tumor necrosis factor (TNF) | Serum/plasma | 18.27 | 9.14 | 2/19/2025 |
| Factor II (F2) | Plasma | 5.7 | 2.85 | 5/15/2025 |
| Factor IX (F9) | Plasma | 6.89 | 3.44 | 2/19/2025 |
| Factor V (F5) | Plasma | 5.33 | 2.66 | 2/19/2025 |
| X Factor (F10) | Plasma | 5.53 | 2.77 | 5/15/2025 |
| Factor XI (F11) | Plasma | 5.1 | 2.55 | 2/19/2025 |
| Ferritin | Serum/plasma | 12.87 | 6.43 | 2/11/2026 |
| Iron | Serum/plasma | 25.24 | 12.62 | 4/13/2026 |
| Fibrinogen | Plasma | 10.18 | 5.09 | 9/9/2026 |
| Folate | Serum/plasma | 11.16 | 5.58 | 9/3/2025 |
| Alkaline phosphatase (ALP) bone isoenzyme | Serum/plasma | 6.6 | 3.3 | 5/15/2025 |
| Alkaline phosphatase (ALP), hepatobiliary type | Serum/plasma | 6 | 3 | 2/19/2025 |
| Tartrate-Resistant Acid Phosphatase (TRAP) | Serum/plasma | 10.8 | 5.4 | 2/19/2025 |
| Phosphate | Serum/plasma | 7.65 | 3.83 | 5/6/2026 |
| Fructosamine | Serum/plasma | 2.3 | 1.15 | 9/3/2025 |
| Glycine | Serum/plasma | 17.41 | 8.7 | 8/8/2025 |
| Glucose | Serum/plasma | 4.67 | 2.33 | 5/6/2026 |
| Haptoglobin | Serum/plasma | 8.61 | 4.3 | 8/13/2025 |
| Hematocrit | Whole blood | 2.81 | 1.4 | 2/11/2026 |
| Hemoglobin (Hb) | Whole blood | 2.67 | 1.34 | 4/13/2026 |
| Hemoglobin A1c (IFCC) | Whole blood | 1.63 | 0.82 | 9/9/2026 |
| Hemoglobin A1c (NGSP) | Whole blood | 1.17 | 0.59 | 2/11/2026 |
| Mean corpuscular hemoglobin (HGM) | Whole blood | 0.75 | 0.38 | 2/11/2026 |
| Total homocysteine (tHcy) | Serum/plasma | 6.09 | 3.05 | 2/19/2025 |
| Antimullerian hormone | Serum/plasma | 19.2 | 9.6 | 2/19/2025 |
| Thyroid Stimulating Hormone (TSH) | Serum/plasma | 17.82 | 8.91 | 3/27/2026 |
| Follicle Stimulating Hormone (FSH) | Serum/plasma | 9.47 | 4.74 | 5/15/2025 |
| Luteinizing Hormone (LH) | Serum/plasma | 25.15 | 12.58 | 5/15/2025 |
| Immunoglobulin A (IgA) | Serum/plasma | 7.46 | 3.73 | 8/13/2025 |
| Immunoglobulin G (IgG) | Serum/plasma | 3.49 | 1.75 | 8/13/2025 |
| Immunoglobulin M (IgM) | Serum/plasma | 5.9 | 2.95 | 8/13/2025 |
| Insulin | Serum/plasma | 25.44 | 12.72 | 2/11/2026 |
| Interleukin-6 (IL-6) | Serum/plasma | 31.95 | 15.97 | 2/19/2025 |
| Leukocytes | Whole blood | 11.1 | 5.55 | 2/11/2026 |
| Lymphocytes | Whole blood | 10.53 | 5.26 | 2/11/2026 |
| Lipase | Serum/plasma | 7.64 | 3.82 | 3/5/2025 |
| Lipoprotein (a) | Serum/plasma | 10.2 | 5.1 | 3/27/2025 |
| Magnesium | Serum/plasma | 2.65 | 1.33 | 4/13/2026 |
| Mean corpuscular volume (MCV) | Whole blood | 0.77 | 0.39 | 2/11/2026 |
| Methylmalonate (MMA) | Serum/plasma | 7.2 | 3.6 | 2/19/2025 |
| Monocytes | Whole blood | 13.98 | 6.99 | 2/11/2026 |
| Neutrophils | Whole blood | 12.55 | 6.27 | 2/11/2026 |
| Osteocalcin | Serum/plasma | 8.73 | 4.37 | 2/28/2025 |
| Parathormone (PTH) | Serum/plasma | 14.72 | 7.36 | 2/11/2026 |
| Plasminogen | Plasma | 5.69 | 2.85 | 2/19/2025 |
| Platelet Distribution Width (PDW) | Whole blood | 3.84 | 1.92 | 2/19/2025 |
| Proportion of large platelets (P-LCR) | Whole blood | 6.78 | 3.39 | 2/19/2025 |
| Plateletcrit | Whole blood | 6.44 | 3.22 | 2/19/2025 |
| Potassium | Serum/plasma | 3.9 | 1.95 | 5/6/2026 |
| Partial pressure of carbon dioxide | Whole blood | 4.8 | 2.4 | 3/5/2025 |
| Progesterone | Serum/plasma | 18.5 | 9.25 | 2/19/2025 |
| Prolactin | Serum/plasma | 44.97 | 22.48 | 8/8/2025 |
| N-terminal propeptide of type I procollagen (PINP) | Serum/plasma | 8.8 | 4.4 | 5/15/2025 |
| Amyloid beta protein 40 (Aβ40) | Serum/plasma | 6.39 | 3.2 | 2/19/2025 |
| Amyloid beta 42 protein (Aβ42) | Serum/plasma | 6.5 | 3.25 | 2/19/2025 |
| Amyloid beta protein 42/40 | Serum/plasma | 3.33 | 1.67 | 2/19/2025 |
| C-reactive protein (CRP) | Serum/plasma | 34.68 | 17.34 | 8/13/2025 |
| Human epididymal protein 4 (HE4) | Serum/plasma | 7.08 | 3.54 | 2/19/2025 |
| S100B Protein | Serum/plasma | 10.2 | 5.1 | 9/3/2025 |
| Total protein | Serum/plasma | 2.6 | 1.3 | 9/9/2026 |
| Soluble interleukin-2 receptor (sIL-2R) | Serum/plasma | 11.34 | 5.67 | 2/19/2025 |
| Soluble interleukin-6 receptor (sIL-6R) | Serum/plasma | 16.3 | 8.15 | 2/19/2025 |
| Soluble transferrin receptor (sTfr) | Serum/plasma | 6.9 | 3.45 | 8/13/2025 |
| Renina | Serum/plasma | 30.1 | 15.05 | 2/19/2025 |
| Activated protein C resistance (APCR) | Plasma | 1.46 | 0.73 | 2/19/2025 |
| Reticulocyte hemoglobin equivalent (RET-He) | Whole blood | 1.75 | 0.87 | 2/19/2025 |
| Reticulocytes | Whole blood | 9.71 | 4.86 | 2/19/2025 |
| Selenium | Serum/plasma | 7.69 | 3.84 | 4/13/2026 |
| Sex hormone-binding globulin (SHBG) | Serum/plasma | 8.32 | 4.16 | 3/27/2026 |
| Dehydroepiandrosterone Sulfate (DHEAS) | Serum/plasma | 20 | 10 | 6/23/2025 |
| Suppression of tumorigenicity 2 (ST2) | Serum/plasma | 10.5 | 5.25 | 2/19/2025 |
| Sodium | Serum/plasma | 0.55 | 0.27 | 5/6/2026 |
| Phosphorylated Tau 181 (p-tau181) | Serum/plasma | 16.7 | 8.35 | 2/19/2025 |
| Phosphorylated Tau 217 (p-tau217) | Serum/plasma | 10.3 | 5.15 | 2/19/2025 |
| Phosphorylated Tau 231 (p-tau231) | Serum/plasma | 6.33 | 3.17 | 2/19/2025 |
| Prothrombin time (PT) | Plasma | 2.6 | 1.3 | 2/19/2025 |
| Prothrombin Time - International Normalized Ratio (INR) | Plasma | 2.5 | 1.25 | 2/19/2025 |
| Activated Partial Thromboplastin Time (APTT) | Plasma | 2.77 | 1.39 | 2/19/2025 |
| Testosterone | Serum/plasma | 14.35 | 7.18 | 9/11/2026 |
| Testosterone - free | Serum/plasma | 55 | 27.5 | 6/23/2025 |
| Thyroglobulin | Serum/plasma | 10.75 | 5.38 | 2/28/2025 |
| Free thyroxine (FT4) | Serum/plasma | 4.8 | 2.4 | 8/8/2025 |
| Total thyroxine (T4) | Serum/plasma | 6.21 | 3.1 | 3/27/2025 |
| Transferrin | Serum/plasma | 3.87 | 1.93 | 3/25/2026 |
| Transthyretin | Serum/plasma | 10.9 | 5.45 | 2/28/2025 |
| Triglycerides | Serum/plasma | 19.76 | 9.88 | 5/6/2026 |
| Free triiodothyronine (free T3) | Serum/plasma | 5.1 | 2.55 | 2/28/2025 |
| Total triiodothyronine (T3) | Serum/plasma | 6.28 | 3.14 | 8/8/2025 |
| Tryptase | Serum/plasma | 5.6 | 2.8 | 2/19/2025 |
| Thrombomodulin | Plasma | 11.4 | 5.7 | 2/19/2025 |
| Thrombocytes | Whole blood | 7.26 | 3.63 | 2/11/2026 |
| Cardiac troponin I - high sensitivity | Serum/plasma | 11.09 | 5.55 | 9/3/2025 |
| Cardiac Troponin T - high sensitivity | Serum/plasma | 12.23 | 6.12 | 8/8/2025 |
| Uncarboxylated and Unphosphorylated Matrix Gla Protein (uCuP-MGP) | Serum/plasma | 6.9 | 3.45 | 2/19/2025 |
| Urea | Serum/plasma | 13.14 | 6.57 | 5/6/2026 |
| Vitamin A | Serum/plasma | 5.99 | 3 | 3/27/2026 |
| Vitamin B1 (thiamine) | Whole blood | 5 | 2.5 | 5/16/2025 |
| Vitamin C | Serum/plasma | 23.45 | 11.72 | 8/14/2025 |
| Vitamin E | Serum/plasma | 6.52 | 3.26 | 9/3/2025 |
| Vitamin K | Serum/plasma | 38 | 19 | 5/16/2025 |
| Mean platelet volume (MPV) | Whole blood | 2.29 | 1.15 | 2/19/2025 |
| Zinc | Serum/plasma | 8.49 | 4.24 | 4/13/2026 |
| Uric acid | Serum/plasma | 8.25 | 4.13 | 5/6/2026 |
| Hydrogen ion (H+) | Whole blood | 3.5 | 1.75 | 3/5/2025 |
| β2-microglobulin | Serum/plasma | 4.14 | 2.07 | 2/28/2025 |
How to interpret the table
The 0.5 × CVI ratio corresponds to the desirable specification of imprecision based on biological variation. It is not a universal limit: the choice of specification depends on clinical use, method and available information. Values of the same substance may vary between matrices and studies.
Source: Aarsand AK and collaborators, EFLM Biological Variation Database. The data and studies belong to the respective authors. Consult the references and conditions of use on the original base.
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